Fungi le bacteria hna i a nemmi lenglei tthen, “extracellular matrix” asiloah ECM tiah auhmi cu jelly bantuk a si i huhphenhnak tthen le vun bantuk in rian a ttuan. Asinain iScience timi cauk chung i naite ah tuahmi hlathlainak ning in, University of Massachusetts Amherst nih Worcester Polytechnic Institute he riantuan ti in, thilnung hme tete cheukhat ECM nih oxalic acid asiloah a dang a sawhsawh mi acid pawl an um lawngah gel a ser. Zeicatiah ECM nih hin antibiotic doh khawhnak in a kharmi pipe le sii lei thilri hna thurhnawmhnak tiang ah a biapi tukmi rian a ttuan caah, zeitindah thilnung hme tete nih an sticky gel layers an thlen timi hngalhthiamnak nih kan nifatin nunnak caah sullam a ngei.

“Microbial ECMs kong hi ka rak duh zungzal,” tiah Massachusetts Amherst University ah microbiology professor le cauk tialtu upa Barry Goodell nih a chim. "Mi nih ECM cu thilnung hme tete a kilvengtu a cawlcang lomi huhphenhnak lenglei tthen pakhat ah an ruah tawn. Asinain thilnung hmete cell chung le leng ah rawl le enzyme pawl caah lam pakhat zong a si kho."
A khuhnak nih rian tampi a ttuan: a hnahnawhnak nih a sullam cu thilnung hme tete pakhat cio kha hmunkhat ah an i fonh khawh i colony asiloah “biofilms” an ser khawh, cun thilnung hmete tampi nih cutin an tuah tikah, pipe pawl kha a phih khawh hna asiloah sii lei thilri pawl kha a thurhnawmhter khawh hna.
Asinain a vun cu a luh khawhmi a si ve a hau: thilnung hme tete tampi nih ECM hmangin enzyme phunphun le a dang metabolite pawl kha an chuahter hna, an ei duhmi thilri asiloah an chawnh duhmi thilri (a rawkmi thing asiloah ruhro a ngeimi tissue tibantuk) ah an chuahter, cun, enzyme pawl nih an rian an lim tikah, rawl eidinnak rian – ECM hmangin rawl ttha pawl kha an kirter ṭhan hna.
A sullam cu ECM cu a cawlcang lomi huhphenhnak tthen lawng a si lo tinak a si; A ngaingai ti ahcun, Goodell le a hawile nih an langhter bantukin, thilnung hme tete nih an ECM a tthawnnak kha uk khawhnak an ngei i cucaah a luh khawhnak kha an uk khawh. Zeitindah an tuah?
Fungi ah, a chuakmi cu oxalic acid a si, thingram tampi ah a ummi a tlangpi in a ummi organic acid a si, cun, Goodell le a hawile nih an hmuh bantukin, thilnung hme tete tampi nih an chuahmi oxalic acid kha carbohydrates lenglei tthen pawl he i pehtlaih awkah an hman. a nemmi thil pakhat ser. , jelly bantuk ECM.
Asinain phu nih naih deuh in an zoh tikah, oxalic acid nih ECM chuahter lawng si loin “a uk” ti zong an hmuh: carbohydrate-acid cawhmi ah microbes nih oxalic acid tam deuh an chap tikah ECM cu a tthawng deuh. ECM cu a tthawng deuhdeuh tikah, molecule ngan deuh pawl kha microbe chung luh le chuah lo dingin a kham deuhdeuh, cu lio ah molecule hme deuh pawl cu pawngkam in microbe chung luh khawhnak nawl an ngei i cu bantuk cun a si ve.
Hi hmuhmi nih hin fungi le bacteria nih an chuahmi thilri phun dangdang hna nih hi thilnung hme tete hna chungin pawngkam ah zeitindah an luh taktak timi phunglam scientific hngalhthiamnak kha a doh. Goodell le a hawile nih thil sining cheukhat ahcun thilnung hme tete nih nunnak caah asiloah zawtnak ngeihnak ding caah aa hngatchanmi matrix asiloah tissue kha doh awkah a hmete tukmi molecule chuahternak cungah an i hngatchan deuh a hau tiah ruahnak an cheuh. A sullam cu, enzyme ngan deuh pawl nih microbial extracellular matrix chungin an kal khawh lo ahcun, molecule hmete chuahnak zong nih zawtnak chuahternak ah hmunhma nganpi a lak khawh.
"A karlak ah a ummi a lo," tiah Goodell nih a chim, "cuka ahcun thilnung hme tete nih pawngkam pakhatkhat he i remh khawhnak ding caah acidity level kha an uk khawh, enzyme tibantuk molecule ngan deuh cheukhat kha an chiah khawh, cu lioah molecule hme deuh pawl kha ECM chungin fawi tein an luhter khawh hna. "ECM kha oxalic acid in thlennak cu thilnung hmete nih antibiotics le antibiotics in anmah le anmah an i ven khawhnak lam pakhat a si kho men, zeicahtiah hi sii tampi cu a ngan tukmi molecule in an ser. Hi remh khawhnak nih hin antimicrobial thlopnak ah a biapi bikmi dawnkhantu pakhat tei khawhnak ding caah a biapi bikmi a si kho, zeicahtiah ECM kha a luh khawhnak ding caah thlennak nih antibiotics le antimicrobials hna an tthatnak a tthanchoter khawh.

“Microbes cheukhat ah oxalate tibantuk acid hme tete sernak le chuahternak kha kan uk khawh ahcun, microbes chung i a lutmi thil zong kan uk khawh lai, cu nih cun microbial zawtnak tampi kha ttha deuh in thlop khawhnak a kan pek khawh lai,” tiah Goodell nih a chim.
December 2022 ah, microbiologist Yasu Morita nih Ngandamnak Zung in bawmhnak a hmuh i a donghnak ah zunthlum zawtnak caah thlopnak thar, a ttha deuhmi sernak ding caah hlathlainak a tuah.

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