Shanghai Jiaotong University in phu pakhat nih hlathlainak an tuahmi nih a langhter ning ahcun, formic acid cu zunthlum zawtnak hmelchunhnak a si i, Alzheimer zawtnak (AD) a hmasa bik a hmuh khawh. Hmuhchuahmi nih a man a fawimi le a fawimi mibu cheknak caah lam a hunpiak khawh. Dr. Yifan Wang, Dr. Qihao Guo le a hawile nih Frontiers in Aging Neuroscience ah “Zuin chung i Formic Acid kha Alzheimer's Biomarker Thar a si khomi ah ttha tein zohfelnak” timi capar an chuah. An chimmi ah, catialtu hna nih hitin an donghter: "Zuin chung i a ummi Formic acid cu Alzheimer zawtnak hngalh khawhnak caah a ttha tukmi a si... Zun chung i Alzheimer zawtnak hmelchunhnak hmuh khawhnak cu a fawi i a man a fawi. Tar pawl nih an tuah tawnmi sii lei zohfelnak ah telh chih ding a si."
Catialtu hna nih AD, a tlangpi in lungfim lonak phun cu, a karh thluahmahmi thluak le ziaza lei tlamtlinlonak in a lang tiah an fianter. AD zawtnak hmelchunhnak bik hna cu extracellular amyloid β (Aβ) a ttha lomi khonnak, neurofibrillary tau tangles a ttha lomi khonnak le synapse rawhnak hna an si. Sihmanhsehlaw, phu nih an peh rihmi cu, “AD zawtnak a chuahtertu cu tling tein theihthiam a si rih lo.”
Alzheimer zawtnak cu thlopbulnak caah a tlai tuk hlan tiang theih loin a um kho. “A hmunmi le a thli tein a ummi zawtnak a si, a sullam cu a langhnganmi hngalh khawhnak tlamtlin lonak a chuah hlanah kum tampi chung a chuak kho i a hmun kho,” tiah caṭialtu hna nih an ti. "Zawtnak a hramthawknak cu thlen khawh lomi lungfimlonak dirhmun hlan ah a cang, cucu thlopbulnak le thlopnak caah sui thlalang a si. Cucaah, tar pawl ah a hramthawknak Alzheimer zawtnak caah a nganmi cheknak tuah a herh."
Mipi cheknak program nih zawtnak kha a hramthawk tein hmuh khawhnak a bawmh ko nain, atu lio cheknak lam hna cu a zungzal in cheknak caah a har tuk i a man a fak tuk. Positron emission tomography-computed tomography (PET-CET) nih Aβ tlawmpal a ummi kha a hmuh khawh, asinain a man a fak i mizaw hna kha radiation ah a chiah hna, cu lioah Alzheimer zawtnak thlopnak ah a bawmmi biomarker hneksaknak nih cun thluak chung ti hmuh khawhnak dingah a luhhnawhmi thi laknak asiloah lumbar punctures a herh, cucu mizaw hna caah a ttha lomi a si kho.
Hlathlainak tuahtu hna nih hlathlainak zeimawzat nih mizaw hna kha AD zunthlum biomarkers zohfel khawh a si ti an langhter. Zun cheknak cu a luhhnawh lo i a fawi, cucaah mibu cheknak caah a ttha. Asinain scientist pawl nih AD caah zunthlum biomarkers an rak hmuh cang ko nain, zawtnak a hramthawknak hmuh khawhnak caah pakhat hmanh aa tlak lo, a sullam cu thlopnak hmasa bik caah sui thlalang cu hmuh khawh a si rih lo tinak a si.
Wang le a hawi le nih hin Alzheimer zawtnak caah zunthlum biomarker pakhat in formaldehyde hi an rak hlathlai cang. “Naite kum hna ah, a ttha lomi formaldehyde metabolism cu kum he aa pehtlaimi thluak lei tlamtlin lonak a langhtertu bik pakhat ah cohlan a si,” tiah an ti. "Kan hlathlainak hlan nih zunthlum formaldehyde dat le thluak riantuannak karlak ah pehtlaihnak a langhter, cu nih cun zunthlum formaldehyde cu AD zawtnak hmasa bik thlopnak caah a si khomi biomarker a si tiah a langhter."
Sihmanhsehlaw, zawtnak hngalh khawhnak caah biomarker ah formaldehyde hmannak ah tthanchonak a um. Nai ah an chuahmi hlathlainak ah, team nih formaldehyde metabolite timi formate kha biomarker ah a ttha deuh maw ttha lo ti zoh awkah an zoh.
Hlathlainak phu ah hin minung 574 an i tel, cu hna lakah cun a fak ning aa dangmi Alzheimer zawtnak a ngeimi mizaw hna le thluak lei in a dammi control aa telmi hna zong an i tel. Hlathlaitu hna nih aa telmi hna zun le thisen sample pawl kha zun biomarkers aa dannak kawl awkah an hlathlai i lungthin lei zohfelnak an tuah. Aa telmi hna cu an zawtnak thlopnak cungah hram bunh in phu nga ah an ṭhen hna: thluak lei in a ttha mi (NC) minung 71, thluak lei in a tlaumi (SCD) 101, thluak lei tlamtlin lonak (CINM) a um lo (CINM), thluak lei tlamtlin lonak 131, thluak lei tlamtlin lonak (MCI) 158 minung, le BA a ngeimi 113. .
Hlathlainak nih a hmuhmi cu zunthlum formic acid dat cu Alzheimer zawtnak phu vialte ah a sang ngaingai i a ngandammi control pawl he tahchunh tikah thluak tthawnnak a zornak he aa pehtlai, a hmasa bik thluak tthawnnak a zormi phu zong aa tel. Mah nih hin formic acid cu AD a hramthawknak caah a biapi mi biomarker pakhat bantuk in rian a ttuan kho tiah a langhter. “Hi hlathlainak ah hin, zunthlum chung i a ummi formic acid dat cu hngalh khawhnak a zor tikah aa thleng tiah a voikhatnak bik kan thanh,” tiah an ti. "Zuin formic acid nih AD thlopnak ah a dang tein tthatnak a langhter. Cun, zunthlum formic acid cu SCD thlopnak phu ah a karh ngaingai, cucu zunthlum formic acid cu AD thlopnak ah hman khawh a si tinak a si."
Hngalh a nuammi cu, hlathlaitu hna nih zunthlum formate dat le thisen Alzheimer's biomarkers fonh in an hlathlai tikah, mizaw hna zawtnak dirhmun kha a dikthliar in an chimchung khawh ti an hmuh. Sihmanhsehlaw, Alzheimer zawtnak le formic acid karlak pehtlaihnak hngalhthiam awkah hlathlainak tuah chap a hau.
Sihmanhsehlaw, catialtu hna nih an donghnak ah an chimmi cu: “Zu formate le formaldehyde dat cu AD le NC thleidan khawhnak caah hman khawh a si lawng si loin, AD zawtnak dirhmun caah plasma biomarkers chimchungnak a dikthliar zong a tthanchoter khawh. zawtnak thlopnak caah a si khomi biomarkers”.